HCS 2018 Speaker Profiles at EB 2018

Monday, April 23, 2018
HCS/ASIP Symposium: Imaging Biometals in Disease (8:30-10:30 am)

 Iqbal Hamza is a Professor at the University of Maryland and has worked with trace metals for the past 27 years beginning in graduate school.  He joined the University of Maryland in 2002 where he deliberately set out to uncover heme trafficking pathways in eukaryotes because none were known at the time.  Empowered with a three-week crash course in C. elegans genetics at the Cold Spring Harbor Laboratory, his pioneering work with the invertebrate animal model C. elegans demonstrated that this roundworm is exceptional because it does not synthesize heme but rather utilizes environmental heme to manufacture heme-containing proteins.  Dr. Hamza applied the C. elegans genetic and genomic approaches to model and identify previously unknown heme trafficking pathways in vertebrates.  His research group identified Heme Responsive Genes (HRGs) proteins, which coordinate and integrate heme homeostasis in eukaryotes.  Undeterred by the tractability of an organism or limitation of an approach, he uses worms, yeast, zebrafish, mice, and parasites to tackle the question at hand.  The genetic and genomic approaches he established in C. elegans laid the groundwork for discovery of heme transport pathways in parasites.  Since related free-living and parasitic nematodes (helminths) also do not synthesize heme, selective targeting of parasite heme transport pathways could be their Achilles heel.  Dr. Hamza has reviewed articles for over 30 different journals; served as a standing member of the Integrative Nutrition and Metabolic Processes Study Section; is the chair of two different Gordon Research Conferences: the Chemistry and Biology of Tetrapyrroles (2018) and the Cell Biology of Metals (2019); and is a Fellow of the American Association for the Advancement of Science.

Jin-Zhang.jpgMarianne Wessling-Resnick is Professor of Nutritional Biochemistry at Harvard T.H. Chan School of Public Health. Her research program largely focuses on mineral metabolism and in particular, genetic disorders of iron metabolism.  Dr. Wessling-Resnick’s studies have elucidated the role of iron deficiency and overload in the regulation of iron and manganese uptake by the intestinal, pulmonary and olfactory pathways.  Using animal models, her work has defined the function of the iron importer divalent metal transporter-1 and the iron exporter ferroportin to characterize “iron-responsive manganese uptake”. Through these efforts, the pharmacokinetics of pulmonary manganese and iron uptake from the lungs to the blood have been established, and this research has revealed the effects of high iron diet as well as the effects of iron deficiency due to diet and phlebotomy on these pathways.  A major finding has been that iron deficiency promotes manganese absorption across the olfactory tract directly into the brain. Studies of flatiron mice, a genetic model of “ferroportin disease”, have demonstrated ferroportin mediates manganese uptake across the intestinal epithelium. In a companion investigation, her laboratory also studied a different model of hereditary hemochromatosis, the hfe-knockout mouse, to show that decreased expression of the iron regulatory hormone hepcidin upregulates intestinal manganese absorption. These combined investigations have identified a role for hepcidin in manganese metabolism to uncover the molecular basis for iron-responsive manganese uptake.

Image result for Svetlana Lutsenko, Ph.D.Svetlana Lutsenko is a professor of physiology at the Johns Hopkins School of Medicine. Her research focuses on human copper homeostasis. Her team is researching how copper is transported within and between the cells, how biosynthesis of copper-dependent enzymes is controlled and how copper metabolism interacts with other processes, such as lipid homeostasis, RNA biogenesis and hormonal signaling in norm and disease. Dr. Lutsenko received her undergraduate degree in biochemistry from Moscow State University. She earned her Ph.D. from the Institute of Bioorganic Chemistry in Moscow, Russia. She was named a fellow of the American Association for the Advancement of Science in 2012 and serves on the grant review committee for the Institute for Basic Biomedical Sciences at the Johns Hopkins School of Medicine.

Journal of Histochemistry & Cytochemistry Lecture (10:30-11:30 am)

photo-0731v6.jpgSally Ward completed her Ph.D. research in the Department of Biochemistry, Cambridge University, Cambridge, U.K. in 1985 under the mentorship of Professor David Ellar. From 1985-1988 she was a Research Fellow at Gonville and Caius College whilst working at the Department of Biochemistry, Cambridge University. From 1988 to 1990, she held the Stanley Elmore Senior Research Fellowship at Sidney Sussex College and carried out research in Sir Greg Winter’s laboratory at the MRC Laboratory of Molecular Biology in Cambridge. In 1990 she joined the University of Texas Southwestern Medical Center, Dallas, as an Assistant Professor. From 2002-2014, she was a Professor in the Department of Immunology at the same institution and in 2004 was appointed to the Paul and Betty Meek-FINA Professorship in Molecular Immunology. Since 2014, she has been a Professor at Texas A&M University Health Science Center. Her current research includes the use of a combination of fluorescence imaging, protein engineering and in vivo studies to develop therapeutics to treat cancer and autoimmunity. She is a member of the Board of Distinguished Advisors in the Antibody Society and serves on the editorial boards of mAbs and Protein Engineering, Design and Selection.

HCS/AAA Workshop: Specimen Quality Drives Reproducibility (2:00-3:30 pm)

Allison Hubel is Professor of Mechanical Engineering and Director of the Biopreservation Core Resource (BioCoR, www.biocor.umn.edu), a national resource in biopreservation. Dr. Hubel has studied both basic science and translational issues behind preservation of molecules, cells and tissues.  Her research focuses on development of fit-for-purpose protocols for preservation, development of technology to improve preservation/processing of cells, and understanding molecular mechanisms of damage during preservation.  She has developed and offered professional short courses on preservation of cell therapies and biospecimens.  Her work on microfluidic processing of cells is being commercialized. She is a co-principal investigator for the U of MN REACH program that helps faculty commercialize their research. She is a fellow of ASME and AIMBE and a National Blood Foundation Scholar. She has been honored recently with the Outstanding Achievement in Biobanking Award from ISBER.  She has published numerous articles related to preservation and is a former deputy editor of Biopreservation and Biobanking.

Douglas L. Rosene received his B.A. in Psychology from Stanford University and his Ph.D. in Psychology and Neurobiology from the University of Rochester in 1975. He completed a three-year postdoc at Harvard Medical School in Neuroanatomy before assuming a faculty position in the Department of Anatomy and Neurobiology at Boston University School of Medicine. He is co-director for the Laboratory of Cognitive Neurobiology with Dr. Mark Moss.

He is recognized as one of the world’s experts on the anatomy of the temporal lobe limbic system and has published extensively in this area. He is also recognized for his work in the neurobiology of cognitive aging and was Program Director for 15 years of a long-standing NIH Program Project studying the neural bases of cognitive decline using the rhesus monkey as a model of normal human aging. Currently he is principal investigator or co-investigator on several other NIH grants that study various aspects of aging and age-related disease in primate models. A more recent research interest is the neurobiological bases and facilitation of recovery of fine motor function after cortical stroke in the rhesus monkey with his colleague Dr. Tara L Moore. Most recently he has been funded by NSF to study the neurobiological validity of diffusion MRI tractography of the human connectome.

Stephen M. Hewitt  is a Clinical Investigator within the Laboratory of Pathology, National Cancer Institute and serves as head of the Experimental Pathology Laboratory. Stephen received his BA from the Johns Hopkins University, and his MD and PhD degrees from the University of Texas Health Science Center, Houston. He completed his residency in Anatomic Pathology at the NCI.  Dr. Hewitt is Editor-in-Chief of the Journal of Histochemistry & Cytochemistry. Dr Hewitt has co-authored over 250 articles and serves on the editorial board of four peer-reviewed journals.